Expression of Sphingosine-1-phosphate (S1P) on the cerebral vasospasm after subarachnoid hemorrhage in rabbits

PURPOSE:To demonstrate the relationship between of sphingosine-1-phosphate (S1P) expression and subarachnoid hemorrhage (SAH).METHODS:The basilar arteries from a "double-hemorrhage" rabbit model of SAH were used to investigate the relation between S1P expression and SAH. Various symptoms, including blood clots, basilar artery cross-sectional area, and S1P phosphatase expression were measured at day 3, 5, 7, 9.RESULTS: The expression of S1P was enhanced in the cerebral vasospasm after subarachnoid hemorrhage in the rabbits. And S1P expression was consistent with the basilar artery cross-sectional area changes at day 3, 5, 7, 9.CONCLUSION: Sphingosine-1-phosphate expression in the cerebral arterial may be a new indicator in the development of cerebral vasospasm after subarachnoid hemorrhage and provide a new therapeutic method for SAH.

Simpatectomía periférica periarterial cubital en el manejo de la enfermedad de Raynaud / Peripheral sympathectomy periarterial ulnar managing Raynaud disease

El Síndrome de Raynaud (SR) se define como una entidad, que afecta los vasos sanguíneos de las porciones dístales del cuerpo (dedos, orejas, nariz) y cuya característica clínica es la presencia de ataques episódicos de vasoespasmo, se explica por una hipersensibilidad local de las arterias digitales al frío, con una intensificación de esta anormalidad por la estimulación simpática normal, que generan isquemia tisular; aunque es una entidad de presentación alarmante, es importante reconocer el comportamiento benigno de ésta. Actualmente se han reconocido varios factores que influyen en la presentación del síndrome y que han permitido enfocar el manejo de estos pacientes. La simpatectomía periférica peri arterial es una alternativa para el manejo de estos pacientes sintomáticos que no responden con tratamiento conservador.

Raynaud’s syndrome is defined as an entity that affects the blood vessels of the distal portions of the body (fingers, ears, nose) and whose clinical feature is the presence of episodic attacks of vasospasm can be explained by a local hypersensitivity digital arteries to cold, with an intensification of this abnormality by normal sympathetic stimulation, which generates tissue ischemia, although a filing entity alarming, it is important to recognize this benign behavior. Have now been recognized several factors that influence the presentation of the syndrome, which allowed focus on the management of these patients. Periarterial peripheral sympathectomy is an alternative for the management of symptomatic patients who do not respond to conservative treatment.